tcel93 HCC1937

The tumor was classified as TNM Stage ⅡB, grade 3BRCA1 analysis revealed that the cell line is homozygous for the BRCA1 5382C mutation, whereas the lymphoblastoid cell line derived from the same patient is heterozygous for the same mutationThis mutation was present in two other family members; an identical sister also developed breast cancerThe cell line has an acquired mutation of TP53 with wild-type allele loss; an acquired homozygous deletion of the PTEN gene, and loss of heterozygosity at multiple loci known to be involved in the pathogenesis of breast cancerThe cells are negative for expression of Her2-neu and for expression of p53. HCC1937 is positive for the epithelial cell specific marker Epithelial Glycoprotein 2(EGP2) and for cytokeratin 19. The cells are negative for expression of estrogen receptor(ER) and progesterone receptor(PR).