tcsc2410 Ciprofloxacin

Ciprofloxacin is a fluoroquinolone antibiotic, exhibiting potent antibacterial activity.

In Vitro: Ciprofloxacin is a fluoroquinolone antibiotic, exhibiting potent antibacterial activity^[1]. Ciprofloxacin (CIP) shows potent activity against Y. pestis with MIC₉₀ of 0.03 μg/mL^[2].

In Vivo: Ciprofloxacin (1 mg/L) induces glutathione-S-transferase (GST) activity, in contrast with inhibited GST and Catalase (CAT) of larvae exposed to enrofloxacin. Ciprofloxacin (≥10 μg/L) and enrofloxacin are ecotoxic for development, growth, detoxifying, and oxidative stress enzymes in anuran amphibian larvae^[1]. In a murine model of pneumonic plague, Ciprofloxacin (30 mg/kg, i.p.) results in a drug exposure which is similar to the drug exposure observed in human following a 500 mg dose of oral Ciprofloxacin. Intraperitoneal Ciprofloxacin reduces the lung bacterial load compare to controls treated with intraperitoneal PBS^[3].