tcsc0157 3-Aminobenzamide

3-Aminobenzamide is a potent inhibitor of PARP with IC₅₀ of appr 50 nM in CHO cells, and acts as a mediator of oxidant-induced myocyte dysfunction during reperfusion.

IC50 & Target: IC50: 50 nM (PARP)^[1]

In Vitro: 3-Aminobenzamide (>1 μM) causes more than 95% inhibition of PARP activity without significant cellular toxicity. INO-1001 significantly sensitizes CHO cells by blocking most of the DNA repair occurring between radiation fractions^[1]. 3-Aminobenzamide significantly improves endothelial function by enhancing the acetylcholine-induced, endothelium-dependent, nitric oxide mediated vasorelaxation after exposure with 400 μM H₂O₂^[2].

In Vivo: In a db/db (Leprdb/db) mouse model, 3-Aminobenzamide ameliorates diabetes-induced albumin excretion and mesangial expansion, and also decreases diabetes-induced podocyte depletion^[3]. 3-Aminobenzamide (1.6 mg/kg via intracerebral injection) prevents NAD⁺ depletion and improves water maze performance after controlled cortical impact (CCI) in mice^[4].