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BioChemicals
CU CPT 22
tcsc0028870
CU CPT 22
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AVAILABLE SIZES
5mg
10mg
25mg
$
271.00
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ORDERING INFORMATION
International
TAICLONE BIOTECH CORP.
order@taiclone.com
+886-2-2735-9682
+886-2-2735-9807
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Western blot (WB)
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Product Description
CU CPT 22 is a toll-like receptor 1 and 2 (
TLR1/2
) inhibitor with an
IC
50
of 0.58 µM.
IC50 & Target: IC50: 0.58 μM (TLR1/2)
[1]
In Vitro:
CU CPT 22 is a toll-like receptor 1 and 2 (TLR1/2) inhibitor with an IC
50
of 0.58±0.09 µM. It is demonstrated that CU CPT 22 is able to compete with Pam
3
CSK
4
for binding to TLR1/2 with an inhibition constant (K
i
) of 0.41±0.07 µM, which is consistent with its potency observed in the whole cell assay. Increasing the concentration of CU CPT 22 to 6 µM decreases the anisotropy to background levels. It is found that CU CPT 22 inhibits TLR1/2 signaling without affecting other TLRs, showing it is highly selective in intact cells. CU CPT 22 is found to have no significant cytotoxicity at various concentrations up to 100 µM in RAW 264.7 cells. The result demonstrates that CU CPT 22 can inhibit about 60% of TNF-αand 95% of IL-1β at 8 µM
[1]
.
Information
CAS No
1416324-85-0
Formula
C
19
H
22
O
7
Clinical Information
clinicalinformation
Pathway
Immunology/Inflammation
Target
Toll-like Receptor (TLR)
Specifications
Purity / Grade
>98%
Solubility
DMSO : ≥ 125 mg/mL (344.95 mM)
Smiles
smiles
Misc Information
Observed Molecular Weight
362.37
related data
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