Application

ACHN may be of use for antiproliferative studies using human interferons or interferon inducers.

Tissue

Human kidney; derived from metastatic site: pleural effusion

Morphology

epithelial

Application

Electron photomicrographs demonstrate cytoplasmic distribution of Weibel-Palade bodies and tissue-specific organelles, characteristics of differentiated endothelial cell functions such as angiogenesis, homeostasis/thrombosis, blood pressure and inflammati

Tissue

Human umbilical vein/vascular endothelium

Morphology

endothelial

Application

The World Organization for Animal Health(OIE) uses these cells for routine diagnosis of rabies. This cell line has been used as a host for transformation with expression vectors containing selectable and amplifiable marker DNAs.

Tissue

Hamster kidney

Morphology

fibroblast

Application

OP9 cells can be used to coculture mouse embryonic stem cells(ES cells) to induce the differentiation of embryonic stem(ES) cells into blood cells of erythroid, myeloid, and B cell lineages. Cocultivation with OP9 does not require exogenous growth factors

Tissue

Mouse bone marrow/stroma

Morphology

fibroblast-like

Application

The cells provide a homogenous, rapidly proliferating model system for studying normal human osteoblast differentiation, osteoblast physiology, and hormonal, growth factor, and other cytokine effects on osteoblast function and differentiation.

Tissue

Human bone

Morphology

osteoblast

Application

These cell lines are good models for studying in vitro osteoblast differentiation, particularly ECM signaling. They have behavior similar to primary calvarial osteoblasts.

Tissue

Mouse bone/calvaria

Morphology

fibroblast