EIPA hydrochloride - tcsc0103821

Product Description

EIPA (L593754) hydrochloride is an orally active TRPP3 channel inhibitor with an IC50 of 10.5 μM. EIPA hydrochloride also

enhances autophagy by inhibiting Na+/H+-exchanger 3 (NHE3). EIPA hydrochloride inhibits macropinocytosis as well.

EIPAhydrochloride can be used in the research of inflammation and cancers, such as gastric cancer, colon carcinoma, pancreaticcarcinoma[1][2][3][5].

Information

CAS No1345839-28-2

FormulaC₁₁H₁₉Cl₂N₇O

PathwayMembrane Transporter/Ion Channel
Neuronal Signaling
Autophagy
Immunology/Inflammation
GPCR/G Protein

TargetTRP Channel
Sodium Channel
Autophagy
COX
Prostaglandin Receptor

Specifications

FormLight yellow to yellow (Solid)

Purity / Grade99.92%

Misc Information

Storage Instruction4°C, sealed storage, away from moisture
In solvent : -80°C, for 6 months
-20°C, for 1 month
(sealed storage, away from moisture)

Alternative Names2-Pyrazinecarboxamide, 3-amino-N-(aminoiminomethyl)-6-chloro-5-[ethyl(1-methylethyl)amino]-, hydrochloride (1:1)

Calculated Molecular Weight336.22

References[1]. Dai XQ, et al. Inhibition of TRPP3 channel by MK-870 and analogs. Mol Pharmacol. 2007 Dec;72(6):1576-85.
[2]. Shi H, et al. Na+/H+ Exchanger Regulates Amino Acid-Mediated Autophagy in Intestinal Epithelial Cells. Cell Physiol Biochem. 2017;42(6):2418-2429.
[3]. Zhu BY, et al. A new HDAC inhibitor cinnamoylphenazine shows antitumor activity in association with intensive macropinocytosis

tcsc0103821 EIPA hydrochloride

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