Product Description
This gene encodes a small glycolipid transport protein which acts as a substrate specific co-factor for the lysosomal enzyme beta-hexosaminidase A. Beta-hexosaminidase A, together with GM2 ganglioside activator, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Mutations in this gene result in GM2-gangliosidosis type AB or the AB variant of Tay-Sachs disease. Alternative splicing results in multiple transcript variants.
Information
Research AreaSignal Transduction
Species ReactivityHomo sapiens (Human)
TargetGM2A
Specifications
FormLiquid or Lyophilized powder (remark your requirement when placing the order)
Storage BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Recommended DilutionWe recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.
Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C.
Our default final concentration of glycerol is 50%. Customers could use it as reference.
SourceE.coli
Purity / Grade>85% as determined by SDS-PAGE.
Gene Expression32-193aa; Full Length of Mature Protein
Misc Information
Storage InstructionStore at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
liquid form is 6 months at -20°C/-80°C.
The shelf life of lyophilized form is 12 months at -20°C/-80°C
Alternative NamesCerebroside sulfate activator protein; ganglioside GM2 activator; Ganglioside GM2 activator isoform short; Ganglioside GM2 activator precursor; GM2 activator; GM2 AP; GM2 ganglioside activator; GM2 ganglioside activator protein; GM2-AP; GM2A; GM2AP; OTTHUMP00000160619; SAP 3; SAP-3; SAP3; SAP3_HUMAN; Shingolipid activator protein 3; Sphingolipid activator protein 3
Calculated Molecular Weight33.6 kDa
SequenceSSFSWDNCDEGKDPAVIRSLTLEPDPIIVPGNVTLSVMGSTSVPLSSPLKVDLVLEKEVAGLWIKIPCTDYIGSCTFEHFCDVLDMLIPTGEPCPEPLRTYGLPCHCPFKEGTYSLPKSEFVVPDLELPSWLTTGNYRIESVLSSSGKRLGCIKIAASLKGI
TagsN-terminal 6xHis-SUMO-tagged
NotesRepeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.