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BioChemicals
Tosedostat
Tosedostat
100mg
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AVAILABLE SIZES
c21h30n2o6
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0.00
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ORDERING INFORMATION
International
TAICLONE BIOTECH CORP.
order@taiclone.com
+886-2-2735-9682
+886-2-2735-9807
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Product Description
No product descriptions available. Please refer to the product information & specifications for details.
Information
CAS No
casno
Formula
238750
-
77
-
1
Clinical Information
clinicalinformation
Pathway
Aminopeptidase
Target
Tosedostat is an
aminopeptidase
inhibitor. IC50 & Target: Aminopeptidase
[1]
In Vitro:
Treatment of HL-60 cells with Tosedostat (CHR-2797) leads to an increase in the secretion of Stanniocalcin 2 (STC2) protein into the growth medium. Increases in
SLC7A11
expression are detectable at 60 nM Tosedostat and as early as 2 h posttreatment. The IC
50
s for inhibition of proliferation by Tosedostat in U-937 and HuT 78 cell lines are 10 nM and >10 μM, respectively. Tosedostat treatment increases expression of amino acid deprivation response (AADR) genes in U-937 cells but not in HuT 78 cells
[1]
. By 24 h with 0.01 μM Tosedostat the mean MCA production is reduced to 77.8% of the untreated control cells
similarly the MCA production is reduced to 51.3% with 1 μM, 38.5% with 5 μM, and 35.3% with 10 μM Tosedostat
[2]
.
In Vivo:
Tosedostat (CHR-2797) is active as an anticancer agent
in vivo
in rodent cancer models, and a dose-response relationship has been shown in two models. The effect of Tosedostat is less apparent when the tumor burden is higher before treatment
[1]
.
Specifications
Purity / Grade
406.47
Solubility
Launched
Smiles
smiles
Misc Information
Alternative Names
1740
Observed Molecular Weight
CHR-2797
related data
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