tcel91 HBL-100

The epithelial cell line HBL-100 has been derived by E.V. Gaffney and associates fromthe milk of a nursing mother and obtained 3 days after delivery. Although there was noevidence of a breast lesion in the milk donor, and the patient had no family history ofbreast cancer, the karyotype of the recovered cells was abnormal as early as passage 7.This line was able to synthesize a small amount of lactose and would respond toprolactin or estrogen by producing increased amounts of casein. Electron micrographsrevealed microvilli, tonofibrils and desmosomes.