tcba13654 GAPDH Polyclonal Antibody

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Product Description

This gene encodes a member of the glyceraldehyde-3-phosphate dehydrogenase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The product of this gene catalyzes an important energy-yielding step in carbohydrate metabolism, the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate in the presence of inorganic phosphate and nicotinamide adenine dinucleotide (NAD). The encoded protein has additionally been identified to have uracil DNA glycosylase activity in the nucleus. Also, this protein contains a peptide that has antimicrobial activity against E. coli, P. aeruginosa, and C. albicans. Studies of a similar protein in mouse have assigned a variety of additional functions including nitrosylation of nuclear proteins, the regulation of mRNA stability, and acting as a transferrin receptor on the cell surface of macrophage. Many pseudogenes similar to this locus are present in the human genome. Alternative splicing results in multiple transcript variants.


Research AreaEpigenetics & Nuclear Signaling, Epigenetic Modifications, Epigenetic Modifications_Methylation, Epigenetics & Nuclear Signaling, Epigenetic Modifications, Epigenetic Modifications_Methylation,
Species ReactivityHuman, Mouse, Rat
Host SpeciesRabbit
Immunogen / Amino acidsRecombinant fusion protein containing a sequence corresponding to amino acids 1-335 of human GAPDH (NP_002037.2).


Storage BufferBuffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Recommended DilutionWB 1:1000 - 1:2000

Misc Information

Storage InstructionStore at -20℃. Avoid freeze / thaw cycles.
Alternative NamesG3PD;GAPD;HEL-S-162eP
Gene ID2597 (human);
Calculated Molecular Weight31kDa/36kDa
PurificationAffinity purification
Cellular LocationCytoplasm,Membrane,Nucleus,cytoskeleton,cytosol,perinuclear region,
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