tcba13517 Phospho-RB1-S807 mAb

Data sheet

Download PDF Datasheet

Technical Inquries

Submit Review

Product Description

The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.

Information

ApplicationWB, IHC, IF
Research AreaCancer, Cell cycle, Cell Biology, Cell Cycle, Epigenetics,
Species ReactivityHuman, Mouse, Rat
Host SpeciesRabbit
IsotypeIgG

Specifications

FormLiquid
Storage BufferBuffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Recommended DilutionWB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50 - 1:200

Misc Information

Storage InstructionStore at -20℃. Avoid freeze / thaw cycles.
Alternative NamesOSRC;p105-Rb;pp110;PPP1R130;pRb;RB
SwissProtP06400
Gene ID5925 (human);
Calculated Molecular Weight106kDa
PurificationAffinity purification
Cellular LocationNucleus,
Get valuable resources and offers directly to your email.