tcba7135 ACVR2A Polyclonal Antibody

Data sheet

Download PDF Datasheet

Technical Inquries

Submit Review

Product Description

This gene encodes a receptor that mediates the functions of activins, which are members of the transforming growth factor-beta (TGF-beta) superfamily involved in diverse biological processes. The encoded protein is a transmembrane serine-threonine kinase receptor which mediates signaling by forming heterodimeric complexes with various combinations of type I and type II receptors and ligands in a cell-specific manner. The encoded type II receptor is primarily involved in ligand-binding and includes an extracellular ligand-binding domain, a transmembrane domain and a cytoplasmic serine-threonine kinase domain. This gene may be associated with susceptibility to preeclampsia, a pregnancy-related disease which can result in maternal and fetal morbidity and mortality. Alternative splicing results in multiple transcript variants of this gene.

Information

ApplicationWB, IHC, IF
Research AreaStem cells, Cell Biology, Metabolism, Amino Acids,
Species ReactivityHuman, Mouse, Rat
Host SpeciesRabbit
IsotypeIgG

Specifications

FormLiquid
Storage BufferBuffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Recommended DilutionWB 1:500 - 1:2000
IHC 1:100 - 1:200
IF 1:50 - 1:200

Misc Information

Storage InstructionStore at -20℃. Avoid freeze / thaw cycles.
Alternative NamesACTRII;ACVR2
SwissProtP27037
Gene ID92 (human);
Calculated Molecular Weight45kDa/57kDa
PurificationAffinity purification
Cellular LocationMembrane,Single-pass type I membrane protein,
Get valuable resources and offers directly to your email.