Product Description
This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Alternative splicing results in multiple transcript variants.
Information
ApplicationWB, IHC, IF, IP
Research AreaCancer, Stem cells, Apoptosis, Autophagy pathway, AKT pathway, Neuroscience, Cell Biology, Metabolism, Neurodegeneration, PI3K-Akt pathway,
Species ReactivityHuman, Mouse, Rat
Host SpeciesRabbit
IsotypeIgG
Specifications
FormLiquid
Storage BufferBuffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Recommended DilutionWB 1:500 - 1:2000
IHC 1:50 - 1:100
IF 1:50 - 1:100
IP 1:50 - 1:200
Misc Information
Storage InstructionStore at -20℃. Avoid freeze / thaw cycles.
Alternative NamesBcl-2; PPP1R50; BCL2
Calculated Molecular Weight22kDa/26kDa
Observed Molecular Weight26KDa
PurificationAffinity purification
Cellular LocationEndoplasmic reticulum membrane,Mitochondrion outer membrane,Nucleus membrane,Single-pass membrane protein,