tcsc7244 AE0047 Hydrochloride

AE0047 Hydrochloride is a calcium blocker, used in the research of hypertensive disease.

IC50 & Target: Calcium Channel^[1]

In Vitro: AE0047 Hydrochloride (4e) is a calcium antagonist^[1]. AE0047 inhibits [³H]nimodipine binding to rat cardiac membrane homogenate with an IC₅₀ of 0.26 nM^[2]. AE0047 (1 μM) inhibits the high K⁺-evoked vascular smooth muscle contraction, and also inhibits [³H]PN200-110 binding with a K_i of 40.9 nM^[3].

In Vivo: AE0047 (3 mg/kg) shows antihypertensive effect, and reduces systolic blood pressure with ED₃₀ of 1.1 mg/kg^[2]. AE0047 (1 or 3 mg/25g SP diet) inhibits blood pressure elevation and improves endothelium-dependent relaxation in response to acetylcholine in aorta isolated from stroke-prone spontaneously hypertensive rats (SHRSP)^[4].