tcsc6762 RP 70676

RP 70676 is a potent inhibitor of ACAT, with IC₅₀ of 25 and 44 nM for rat and rabbit ACAT.

IC50 & Target: IC50: 25 nM (Rat ACAT), 44 nM (Rabbit ACAT)^[1]

In Vitro: RP 70676 is a potent inhibitor of rabbit arterial ACAT (IC₅₀ = 40 nM) and has been shown to be an effective inhibitor of ACAT derived from a number of tissues and species including man. The IC₅₀ values range from 21 nM for hamster liver ACAT to 108 nM for enzyme from the intestine of cholesterol fed rabbits; in human hepatic tissues the mean IC₅₀ is 44 nM. In whole cell P388D, murine macrophages the compound has an IC₅₀ of 540 nM.

In Vivo: RP 70676 (10 mg/kg, p.o.) is well absorbed with plasma levels in NZW rabbits^[1].