tcsc3394 NMS-P715 (analog)

NMS-P715 analog is an inhibitor of MPS1, with an IC₅₀ of 84 nM.

IC50 & Target: IC50: 84 nM (MPS1)^[1]

In Vitro: NMS-P715 analog (Compound 14) is an inhibitor of MPS1, with an IC₅₀ of 84 nM; also less active on Aur-A, CDK2/A and PLK1 (IC₅₀, 1.45, >10, 0.237 μM). In addition, NMS-P715 analog shows inhibitory effect on human tumor cell line (A2780) with an IC₅₀ of 150 nM.