tcsc3351 ML355

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Product Description

ML355 is a potent and selective inhibitors of 12-Lipoxygenase(12-LOX) with IC50 of 0.34 μM, excellent selectivity over related lipoxygenases and cyclooxygenases, and possess favorable ADME properties.

IC50 value: 0.34 μM [1]

Target: 12-LOX

ML355 inhibits PAR-4 induced aggregation and calcium mobilization in human platelets and reduce 12-HETE in β-cells.

Information

CAS No1532593-30-8
FormulaC21H19N3O4S2
Clinical Informationclinicalinformation
PathwayMetabolic Enzyme/Protease
Target5-Lipoxygenase

Specifications

Purity / Grade>98%
SolubilityDMSO : ≥ 42 mg/mL (95.13 mM)
Smilessmiles

Misc Information

Observed Molecular Weight441.52
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