tcsc3268 Nexturastat A

Nexturastat A is a potent and selective HDAC6 inhibitor with IC50 of 5 nM; no inhibition on other HDAC forms.

IC50 value: 5 nM [1]

Target: HDAC6 inhibitor

Nexturastat A displayed low micromolar activity compared to the low nanomolar activity against HDAC6. Moreover, it also demonstrated high levels of selective inhibition against members of the related Class 2 HDAC isozymes reaching >1000-fold selective in some cases. Compared to the pan-selective HDACI LBH589, Nexturastat A is approximately 100-fold less potent in inducing murine B16 melanoma cell death.