tcsc3252 APD668

APD668 is a potent GPR119 agonist with EC50 of 2.7 nM and 33 nM for hGPR119 and ratGPR119 respectively..

IC50 value: 2.7 nM (EC50) [1]

Target: GPR119

Chronic treatment withAPD668 showed for the first time that blood glucose and glycated hemoglobin (HbA1c) levels could be significantly reduced in Zucker Diabetic Fatty (ZDF) rats over several weeks of dosing. APD668 was the rst compound with this

mechanism of action to be progressed into clinical development for the treatment of diabetes.