tcsc3227 MIM1

MIM-1 is an inhibitor of myeloid cell factor 1 (Mcl-1).

IC50 & Target: Mcl-1^[1]

In Vitro: MIM-1 selectively targets the BH3 binding groove of Mcl-1, with Bak-dependent apoptotic activity. To estimate the sensitivity of HA and T98G cells to the apoptosis inhibitor MIM-1, the colorimetric MTT assay is used to detect cell viability and to determine the IC₅₀ value. The IC₅₀ value of the HA cell line is almost 5-fold lower (16.10 µM) compared with the IC₅₀ of the T98G cell line (80.20 µM) after MIM-1 inhibitor treatment.