tcsc3225 LDN-27219

LDN-27219 is a potent inhibitor of hTGase(Tissue transglutaminase) with an IC50 of 0.6 uM.

IC50 value: 0.6 uM [1]

Target: hTGase inhibitor

LDN-27219 is a potent inhibitor of the enzyme(hTGase), producing 100% inhibition at the screening concentration of 10 uM. To examine the enzyme selectivity of LDN-27219, it was tested as an inhibitor of coagulation Factor XIIIa and caspase 3. At concentrations as high as 50 íM, the compound had no effect on the activities of either of these enzymes. LDN-27219 was found to be nontoxic at concentrations as high as 100 íM in an assay that measures the viability of HT1080 cells, a fibrosarcoma tumor cell line.