tcsc3202 AGN 205728

AGN 205728 is a potent and selective RARγ antagonist with Ki/IC95 values of 3 nM/ 0.6 nM; no inhibiton on RARα and RARβ.

IC50 value: 3 nM/ 0.6 nM(Ki/IC95)

Target: RARγ antagonist

More information can be found in the following patent, Compound 7a.

Preparation of disubstituted chalcone oximes having RARγ retinoid receptor antagonist activity

By Tsang, Kwok Yin; Sinha, Santosh; Liu, Xiaoxia; Bhat, Smita; Chandraratna, Roshantha A.

From PCT Int. Appl. (2005), WO 2005066115 A2 20050721.