tcsc3178 iCRT 14

iCRT 14 is a novel potent inhibitor of β-catenin-responsive transcription (CRT), with IC₅₀ of 40.3 nM against Wnt responsive STF16 luciferase.

IC50 & Target: IC50: 40.3 nM (Wnt responsive STF16 luciferase)^[1]

In Vitro: iCRT14 can interfere with TCF binding to DNA in addition to its ability to influence TCF-β-cat interaction^[1]. iCRT14 (10, 25, 50 μM) effectively inhibits cell proliferation in BT-549 cells in a dose- and time-dependent manner, but still less potent than iCRT3^[2].

In Vivo: iCRT14 (50 mg/kg, i.p.) markedly decreases CycD1, proliferation of the tumors in HCT116 xenografts^[1].