tcsc3120 Melphalan

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Product Description

Melphalan is an effective DNA alkylating agent, with antitumor activity.

IC50 & Target: DNA Alkylator/Crosslinker[1]

In Vitro: Melphalan is a DNA alkylating agent, used for multiple myeloma[1]. Melphalan-DNA adducts can be visualised in both cultured cells and solid tumour tissue[3].

In Vivo: Melphalan (12 mg/kg, i.p.) increases pharmacological activity with heat in SD rats[2].

Information

CAS No148-82-3
FormulaC13H18Cl2N2O2
Clinical Informationclinicalinformation
PathwayCell Cycle/DNA Damage
TargetDNA Alkylator/Crosslinker

Specifications

Purity / Grade>98%
SolubilityDMSO : 6 mg/mL (19.66 mM; Need ultrasonic); H2O : 4 mg/mL (13.11 mM; ultrasonic and adjust pH to 2 with HCl)
Smilessmiles

Misc Information

Alternative NamesL-PAM
Observed Molecular Weight305.2
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