tcsc3119 Thio-TEPA

Thio-TEPA is a DNA alkylating agent, with antitumor activity.

IC50 & Target: DNA Alkylator^[1]

In Vitro: Thio-TEPA exhibits alkylating activity in rat liver slice incubation. Thio-TEPA does not affect the viability of rat liver slices, and is not accumulated in the slices at all doses of 2, 5, 10 mM^[1].

In Vivo: Thio-TEPA (20 mg/kg, i.p.) with total body irradiation (TBI) enhances donor-type blood chimerism during the first 10 weeks but is not dramatically higher than that of TBI group alone. Thio-TEPA alone improves both short- and long-term engraftment in mice^[2].