tcsc3100 PI-3065

PI-3065 is a potent inhibitor of PI3K p110δ, with IC₅₀ and K_i values of 5 nM and 1.5 nM, and exhibits less potent activity against p110α, p110β, p110γ with IC₅₀s of 910, 600, >10000 nM.

IC50 & Target: IC50: 5 nM (p110δ), 910 nM (p110α), 600 nM (p110β), >10000 nM (p110γ)^[1]

In Vitro: PI-3065 exhibits no inhibition of the growth of 4T1 cells, which do not express detectable levels of p110δ^[1].

In Vivo: PI-3065 (75 mg/kg, p.o.) inhibits the growth of 4T1 tumours in the BALB/c mice without obvious body weight loss^[1].