tcsc2849 DUBs-IN-1

DUBs-IN-1 is an active inhibitor of ubiquitin-specific proteases (USPs), with an IC₅₀ of 0.24 μM for USP8.

IC50 & Target: IC50: 0.24 μM (USP8)^[1]

In Vitro: DUBs-IN-1 (22 f) is an active inhibitor of ubiquitin-specific proteases, with an IC₅₀ of 0.24 μM for USP8. DUBs-IN-1 is inactive toward USP7 (IC₅₀, >100 μM). DUBs-IN-1 and its analogs reduce the viability of HCT116 colon and PC-3 prostate cancer cell lines with IC₅₀s ranging from 0.5 μM to 1.5 μM^[1].