tcsc2848 DUBs-IN-2

DUBs-IN-2 is a potent deubiquitinase inhibitor with an IC₅₀ of 0.28 μM for USP8.

IC50 & Target: IC50: 0.28 μM (USP8)^[1]

In Vitro: DUBs-IN-2 (compound 22 e) is a potent USP8 inhibitor with an IC₅₀ of 0.28 μM, and has no effect on USP7, with an IC₅₀ of >100 μM. DUBs-IN-2 inhibits the viability of HCT116 colon cell line and PC-3 prostate cancer cell line with IC₅₀ values of 0.5-1.5 μM^[1].