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BioChemicals
Ampicillin (sodium)
tcsc2742
Ampicillin (sodium)
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AVAILABLE SIZES
1g
5g
$
257.00
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ORDERING INFORMATION
International
TAICLONE BIOTECH CORP.
order@taiclone.com
+886-2-2735-9682
+886-2-2735-9807
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Product Description
Ampicillin sodium is a broad-spectrum beta-lactam antibiotic against a variety of gram-positive and gram-negative
bacteria
.
IC50 & Target: Bacterial
[1]
In Vitro:
Ampicillin inhibits the growth of
E. coli
of swine origin in a dose-dependent manner. The effective inhibitory concentration of Ampicillin was 2.5 uG/mL
[1]
.
In Vivo:
Ampicillin is very effective in alleviating the symptoms of hemorrhagic enteritis in a 11-week old pig
[1]
. Ampicillin produces maximum concentrations in bile twice as high as in serum. The peak concentration of ampicillin after an oral dose is as twice as high in portal blood as in peripheral blood
[2]
. Ampicillin provides neuroprotection against ischemia-reperfusion brain injury. Ampicillin reduces the activities of MMPs and increases the expression level of GLT-1. Pretreatment with ampicillin significantly reduces medial hippocampal cell death following global forebrain ischemia
[3]
.
Information
CAS No
69-52-3
Formula
C
16
H
18
N
3
NaO
4
S
Clinical Information
clinicalinformation
Pathway
Anti-infection
Target
Antibiotic
Bacterial
Specifications
Form
White to off-white (Solid)
Purity / Grade
≥98.0%
Solubility
H2O : ≥ 200 mg/mL (538.53 mM); DMSO : 200 mg/mL (538.53mM; Need ultrasonic)
Smiles
O=C([C@@H]1N(C2=O)[C@]([C@@H]2NC([C@@H](C3=CC=CC=C3)N)=O)([H])SC1(C)C)O[Na]
Misc Information
Storage Instruction
2-8°C, sealed storage, away from moisture
Alternative Names
D-(-)-α-Aminobenzylpenicillin sodium salt
Observed Molecular Weight
371.38
References
[1]. Chopra SL, et al. Effect of Ampicillin on E. Coli of Swine Origin. Can J Comp Med Vet Sci. 1963 Sep;27(9):223-7.
[2]. Lund B, et al. Ampicillin in portal and peripheral blood and bile after oral administration of ampicillin andpivampicillin. Eur J Clin Pharmacol. 1974;7(2):133-5.
[3]. Lee KE, et al. The neuroprotective mechanism of ampicillin in a mouse model of transient forebrain ischemia. Korean J Physiol Pharmacol. 2016 Mar;20(2):185-92
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