tcsc2690 TCS JNK 5a

TCS JNK 5a is a potent JNK3 inhibitor with a pIC₅₀ of 6.7. TCS JNK 5a also inhibits JNK2 with a pIC₅₀ of 6.5.

IC50 & Target: pIC50: 6.7 (JNK3), 6.5 (JNK2), <5.0 (JNK1), <4.8 (p38α)^[1]

In Vitro: TCS JNK 5a is also screened in a panel of more than 30 kinase assays, including Alk5, c-Fms, CDK-2, EGFR, ErbB2, GSK3β, PLK1, Src, Tie-2 and VegFr2, and is inactive (pIC₅₀<5.0) against all of them^[1].