tcsc2684 CEP-37440

CEP-37440 is a novel potent and selective Dual FAK/ALK inhibitor with IC50 s of 2.3 nM (FAK) and 120 nM(ALK cellular IC50 in 75% human plasma).

IC50 value: 2.3 nM (FAK); 120 nM (ALK cellular IC50 in 75% human plasma)

Target: Dual FAK/ALK

Preparation of fused bicyclic 2,4-diaminopyrimidine derivatives as a dual ALK and FAK inhibitor

By Jacobs, Martin J.; Ott, Gregory R.

From PCT Int. Appl. (2013), WO 2013134353 A1 20130912.