tcsc2681 Mefenamic acid

Mefenamic acid is a non-steroidal anti-inflammatory agent, acting as a competitive inhibitor of hCOX-1 and hCOX-2, with IC₅₀s of 40 nM and 3 μM for hCOX-1 and hCOX-2, respectively.

IC50 & Target: IC50: 40 nM (hCOX-1), 3 μM (hCOX-2)^[1]

In Vitro: Mefenamic acid is a non-steroidal anti-inflammatory agent, acting as a competitive inhibitor of hCOX-1, with IC₅₀s of 40 nM and 3 μM for hCOX-1 and hCOX-2, respectively^[1]. Mefenamic acid (0-100 μM) has cytotoxic effects on KB, Saos-2, and 1321N cells, however, U-87MG cells are resistant to Mefenamic acid^[2].