tcsc2423 Cyproheptadine (hydrochloride)

Cyproheptadine is a histamine receptor antagonist for 5-HT2 receptor with IC50 of 0.6 nM.

Target: 5-HT2 Receptor

Cyproheptadine is a serotonin antagonist and a histamine H2 blocker used as antipruritic, appetite stimulant, antiallergic, and for the post-gastrectomy dumping syndrome, etc. Inhibitory effects of cyclobenzaprine, amitriptyline, and cyproheptadine on mono- and polysynaptic reflex potentials are due to the inhibition of descending serotonergic systems through 5-HT(2) receptors in the spinal cord [1, 2].