tcsc2309 ID-8

ID-8 is a DYRK inhibitor, and sustains embryonic stem cell self-renewal in long-term culture.

IC50 Value:

Target: DYRK

in vitro: the combination of Wnt and ID-8 enhanced hESC replating efficiency, and colonies expressed ALP and displayed undifferentiated morphology. members of the DYRK family are direct targets of ID-8 and that ID-8 enhances Wnt-mediated hESC survival and proliferation via inhibition of DYRKs [1]. ID-8 stimulated proliferation at a steady rate similar to LIF. ID-8 is required to maintain nanog, Sox2, and Rex-1 gene expression [2].

In vivo: