tcsc2303 Proparacaine (Hydrochloride)

Proparacaine Hydrochloride is a voltage-gated sodium channels antagonist with ED50 of 3.4 mM.

IC50 Value: 3.4 mM(ED50) [1]

Target: Sodium Channel

in vitro: Proparacaine is more potent and less toxic than cocaine [1]. Proparacaine significantly increases in FHV-1 (P < 0.01), C. felis, and 28S rDNA Ct values when fusidic acid is used [2].

in vivo: Proparacaine inhibits corneal epithelial migration and adhesion through alteration of the actin cytoskeleton [3]. Proparacaine acts like bupivacaine or lidocaine and produces dose-related spinal blockades of motor function, proprioception and nociception. Intrathecal proxymetacaine also produces longer sensory blockade than motor blockade [4].