tcsc2181 USP7 / USP47 inhibitor

USP7/USP47 inhibitor is a selective ubiquitin-specific protease 7/47 (USP7/USP47) inhibitor, with EC₅₀s of 0.42 μM and 1.0 μM, respectively.

IC50 & Target: EC50: 0.42 μM (USP7), 1.0 μM (USP47)^[1]

In Vitro: USP7/USP47 inhibitor (compound 14) is a selective inhibitor of USP7/USP47 with EC₅₀s of 0.42 μM and 1 μM, respectively. USP7/USP47 inhibitor does not inhibit caspase 3, calpain 1, 20S proteasome, and a panel of representative USPs (USP2, USP5, USP8, USP21, and USP28; EC₅₀ > 31.6 μM). USP7/USP47 inhibitor inhibits the growth of HCT-116 cells with an EC₅₀ of 7.6 μM^[1].