tcsc2038 NMS-873

NMS-873 is a potent, selective allosteric VCP/p97 inhibitor with IC₅₀ value of 30 nM.

IC50 & Target: IC50: 30 nM^[1]

In Vitro: NMS-873 has antiproliferative effect on a panel of tumor cell lines with IC₅₀ values in the range of 0.08 μM to 2 μM. For HCT116 and HeLa cells, the IC₅₀ values are 0.4 μM and 0.7 μM, respectively. NMS-873 reduces VCP sensitivity to trypsin digestion, preventing degradation of the linker-D2 domain. NMS-873 induces clear, dose-dependent accumulation of poly-Ub proteins and stabilization of cyclin E and Mcl-1 at doses consistent with its antiproliferative IC₅₀ value^[1].