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Product Description
Abacavir sulfate (ABC) is a powerful nucleoside analog reverse transcriptase inhibitor (NRTI) used to treat HIV and AIDS.
Target: NRTI
Abacavir is a nucleoside reverse transcriptase inhibitor marketed since 1999 for the treatment of infection with the human immunodeficiency virus type 1 (HIV). Despite its clinical efficacy, abacavir administration has been associated with serious and sometimes fatal toxic events. Abacavir has been reported to undergo bioactivation in vitro, yielding reactive species that bind covalently to human serum albumin, but the haptenation mechanism and its significance to the toxic events induced by this anti-HIV drug have yet to be elucidated.
The mechanism underlying abacavir hypersensitivity syndrome is related to the change in the HLA-B*5701 protein product. Abacavir binds with high specificity to the HLA-B*5701 protein, changing the shape and chemistry of the antigen-binding cleft. This results in a change in immunological tolerance and the subsequent activation of abacavir-specific cytotoxic T cells, which produce a systemic reaction known as abacavir hypersensitivity syndrome.
Information
CAS No188062-50-2
FormulaC28H38N12O6S
Clinical Informationclinicalinformation
PathwayAnti-infection
TargetReverse Transcriptase
Specifications
Purity / Grade>98%
SolubilityDMSO : ≥ 45 mg/mL (67.09 mM)
Smilessmiles
Misc Information
Alternative NamesAbacavir Hemisulfate;ABC sulfate
Observed Molecular Weight670.74
related data
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