tcsc2021 PI3Kγ inhibitor 1

PI3Kγ inhibitor 1 is a PI3Kδ and PI3Kγ inhibitor extracted from patent WO2014004470A1, Compound 168 in Table 4, has IC₅₀s of <100 nM.

IC50 & Target: IC50: <100 nM (PI3Kδ), <100 nM (PI3Kγ), <10 μM (PI3Kα), <10 μM (PI3Kβ)^[1]

In Vitro: In Table 3, PI3Kγ inhibitor 1 (Compound 168) inhibits PI3Kδ, PI3Kγ, PI3Kα and PI3Kβ with IC₅₀s of <100 nM, <100 nM, <10 μM and <10 μM, respectively. PI3Kγ inhibitor 1 inhibits B cell proliferation with an EC₅₀<100 nM.