tcsc1825 Dolastatin 10

Dolastatin 10 is a potent antimitotic peptide, isolated from the marine mollusk Dolabela auricularia, that inhibits tubulin polymerization.







IC50 & Target: Tubulin^[1]

In Vitro: Dolastatin 10 is a unique pentapeptide that isolated from the sea hare Dolabella auricularia. These in vitro data are quite comparable to those of Dolastatin 10 and Auristatin PE, each of which has GI₅₀ values of 10⁻⁵-10⁻⁶ μg/mL (10⁻²-10⁻³ nM) against a similar minipanel of human cell lines^[2]. The antibody-drug conjugate (ADC) comprises the anti-CD30 monoclonal antibody cAC10 conjugated to the cytotoxic agent monomethyl auristatin E (MMAE), a synthetic analog of the tubulin polymerization inhibitor Dolastatin 10^[3].