tcsc1810 LH846

LH846 is a selective inhibitor of CKIδ, with an IC₅₀ of 290 nM, and less potently inhibits CKIα and CKIε, with IC₅₀s of 2.5 μM and 1.3 μM, respectively.

IC50 & Target: IC50: 290 nM (CKIδ), 1.3 μM (CKIε), 2.5 μM (CKIα)^[1]

In Vitro: LH846 is a potent inhibitor of CKIδ, with an IC₅₀ of 290 nM, less potently inhibits CKIα and CKIε, with IC₅₀s of 2.5 μM and 1.3 μM, respectively, and has no effect on CK2. LH846 (3 or 10 μM) inhibits CKIδ-dependent phosphorylation of PER1 in HEK293T cells^[1].