tcsc1744 IOWH-032

IOWH-032 is a novel and potent CFTR inhibitor (IC50=1.01 uM) in T84 and CHO-CFTR cell based assays.

IC50 value: 1.01 uM (CHO-CFTR FLIPR) [1]

Target: CFTR

Profiling of iOWH032 showed it to be a CFTR inhibitor in T84 and CHO-CFTR cell based assays. It also demonstrated statistical significant inhibition at both 100 g & 10 g doses in the mouse closed-loop model. iOWH032 was further profiled in a cecetomized rat model. iOWH032 reduced the fecal output index by ~70%, compared to vehicle (cholera

toxin), up to 8 hours after a single 5 mg/kg po dose.