tcsc1686 WEHI-539 hydrochloride

WEHI-539 hydrochloride is a selective inhibitor of Bcl-X_L with IC₅₀ of 1.1 nM.





IC50 & Target: IC50: 1.1 nM (Bcl-X_L)^[1]

In Vitro: WEHI-539 hydrochloride is a selective inhibitor of Bcl-X_L. WEHI-539 augments Carboplatin induced caspase 3/7 activity, PARP cleavage and annexin V labelling. WEHI-539 as a single agent causes noticeable PARP cleavage in Ovcar-4 (5 μM in Ovcar-4.) and Ovsaho (1 μM in Ovsaho) cells^[2].