tcsc1650 SJB2-043

SJB2-043 is an inhibitor of the native USP1/UAF1 complex with IC₅₀ of 544 nM.



IC50 & Target: IC50: 544 nM (USP1/UAF1)^[1]

In Vitro: SJB2-043 causes a dose-dependent decrease in ubiquitin-specific protease 1 (USP1) levels and a concomitant degradation of inhibitor of DNA-binding-1 (ID1) protein in the K562 cells at a micromolar drug concentration. SJB2-043 also causes a decrease in the levels of other ID proteins, namely ID2 and ID3 in K562 cells. SJB2-043 causes a dose-dependent decrease in the number of viable K562 cells, with an EC₅₀ of approximately 1.07 μM. Moreover, SJB2-043 induces apoptosis of K562 cells in a dose-dependent manner^[1].