tcsc1649 SJB3-019A

SJB3-019A is a potent and novel USP1 inhibitor, 5 times more potent than SJB2-043 in promoting ID1 degradation and cytoxicity in K562 cells with IC₅₀ of 0.0781 μM.



IC50 & Target: IC50: 78.1 nM (ID1)

In Vitro: SJB3-019A (IC₅₀=0.0781 μM) is 5 times more potent than SJB2-043 in promoting ID1 degradation and cytoxicity in K562 cells. SJB3-019A increases the levels of Ub-FANCD2 and Ub-PCNA, and decreases the HR activity^[1].