tcsc1643 StemRegenin 1

StemRegenin 1 is a potent aryl hydrocarbon receptor (AhR) antagonist with IC₅₀ of 127 nM.

IC50 & Target: IC50: 127 nM (AhR)^[1]

In Vitro: StemRegenin 1 (SR1) acts by antagonizing the aryl hydrocarbon receptor (AhR). StemRegenin 1 increases the number of CD34⁺ cells after 5 to 7 days with an EC₅₀ of ~120 nM. StemRegenin 1 inhibits photoaffinity ligand (PAL) binding (IC₅₀=40 nM) These results support the conclusion that StemRegenin 1 -induced CD34⁺ cell expansion is mediated through direct binding and inhibition of the AhR^[1]. An aryl hydrocarbon receptor antagonist, StemRegenin 1 (SR1), robustly promotes ex vivo expansion of human CD34⁺ cells. StemRegenin 1 treatment accelerates the proliferation of CD34⁺ cells and decreases the expression levels of VentX^[2].