Tipiracil (hydrochloride) - tcsc1637

Product Description

Tipiracil (hydrochloride) is a thymidine phosphorylase inhibitor (TPI), used for cancer research.

In Vitro: Tipiracil has antiangiogenic effect, and inhibits proliferation of endothelial cells^[1]. Tipiracil is a potent inhibitor of thymidine phosphorylase, which is the enzyme that degrades FTD^[2].

In Vivo:

Information

CAS No183204-72-0

FormulaC₉H₁₂Cl₂N₄O₂

Clinical Informationclinicalinformation

PathwayCell Cycle/DNA Damage

TargetNucleoside Antimetabolite/Analog

Specifications

FormWhite to off-white (Solid)

Purity / Grade99.32%

SolubilityH2O : 50 mg/mL (179.13 mM; Need ultrasonic);
DMF : < 1mg/mL (insoluble);
DMSO : < 1 mg/mL (insoluble or slightly soluble)

Smilessmiles

Misc Information

Storage InstructionStorage temp. 2-8°C

Observed Molecular Weight279.12

References[1]. Peters GJ, et al. TAS-102: more than an antimetabolite. Lancet Oncol. 2012 Dec;13(12):e518-9.
[2]. Yoshino T, et al. TAS-102 monotherapy for pretreated metastatic colorectal cancer: a double-blind, randomised, placebo-controlled phase 2 trial. Lancet Oncol. 2012 Oct;13(10):993-1001.

tcsc1637 Tipiracil (hydrochloride)

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