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BioChemicals
Trifluridine
tcsc1602
Trifluridine
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AVAILABLE SIZES
50mg
100mg
200mg
$
120.00
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ORDERING INFORMATION
International
TAICLONE BIOTECH CORP.
order@taiclone.com
+886-2-2735-9682
+886-2-2735-9807
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Product Description
Trifluridine is an irreversible
thymidylate synthase
inhibitor, and thereby suppresses
DNA synthesis
. Trifluridine is an antiviral drug for
herpes simplex virus (HSV)
infection.
Biological Activity
:Trifluridine (Trifluorothymidine; 5-Trifluorothymidine; TFT) is an irreversible thymidylate synthase inhibitor, and thereby suppresses
DNA synthesis. Trifluridine is an antiviral drug for herpes simplex virus (HSV) infection.
Information
CAS No
70-00-8
Formula
C
10
H
11
F
3
N
2
O
5
Clinical Information
clinicalinformation
Pathway
Anti-infection
Apoptosis
Cell Cycle/DNA Damage
Target
HSV
Nucleoside Antimetabolite/Analog
Thymidylate Synthase
Specifications
Form
White to off-white (Solid)
Purity / Grade
99.85%
Solubility
DMSO : ≥ 100 mg/mL (337.61 mM)
Smiles
smiles
Misc Information
Storage Instruction
Storage temp. 2-8°C
Alternative Names
Trifluorothymidine; 5-Trifluorothymidine; TFT
Observed Molecular Weight
296.2
References
[1]. Suzuki N, et al. Mode of action of trifluorothymidine (TFT) against DNA replication and repair enzymes. Int J Oncol. 2011 Jul;39(1):263-70.
[2]. Suzuki N, et al. Trifluorothymidine exhibits potent antitumor activity via the induction of DNA double-strand breaks. Exp Ther Med. 2011 May;2(3):393- 397.
[3]. Temmink OH, et al. Irinotecan-induced cytotoxicity to colon cancer cells in vitro is stimulated by pre-incubation withtrifluorothymidine. Eur J Cancer. 2007 Jan;43(1):175-83.
[4]. Okayama T, et al. Involvement of concentrative nucleoside transporter 1 in intestinal absorption of trifluorothymidine, a novel antitumor nucleoside, in rats. J Pharmacol Exp Ther. 2012 Feb;340(2):457-62.
[5]. Novel trifluridine crystal form and preparation method thereof.
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