tcsc1439 Pyridostatin

Pyridostatin is a G-quadruplexe stabilizer, with a K_d of 490 nM.

IC50 & Target: Kd: 490 nM (G-quadruplexe)^[1]

In Vitro: Pyridostatin is a G-quadruplexe stabilizer, with a K_d of 490 nM^[1]. Pyridostatin (PDS) shows neurotoxic activity against primary cortical neurons at 0.01-5 μM, causes DNA double-strand breaks (DSBs) at 1 μM, downregulates BRCA1 in neurons at 1, 2 or 5 μM^[2]. Pyridostatin interacts with G-quadruplex motifs in SRC and alters mRNA levels of damaged genes^[3].