tcsc1408 c-Kit-IN-1

c-Kit-IN-1 is a potent inhibitor of c-Kit and c-Met with IC₅₀s of <200 nM.

IC50 & Target: IC50: <200 nM (c-Met), <200 nM (c-Kit), <2 μM (KDR), <10 μM (PDGFRα), <10 μM (PDGFRβ)^[1]

In Vitro: c-Kit-IN-1 is a c-Kit and c-Met inhibitor extracted from patent 2010051373A1, compound example 45, has an IC₅₀ of <200 nM. c-Kit-IN-1 also inhibits KDR, PDGFR α and β with IC₅₀s of <2 μM, <10 μM and <10 μM, respectively^[1].